Matrix Metalloproteinase-9 (MMP-9)

Blood Test Types

Note
This lab test can be purchased without a physician and drawn at a Quest Diagnostics location. A small draw fee of $ 8 will be applied at checkout. There are no other "hidden" fees unless noted on the lab test.
Doctor/Practitioner
Certain lab tests may come back in the "normal" range. Reference ranges do not always mean "optimal." Patients may still experience symptoms in the "normal" range. It is important to speak with a qualified health practitioner regarding normal vs optimal.
Currently, NY, NJ, and RI state laws prohibit direct-access testing. This lab test cannot be conducted at lab locations within these states at this time.

Matrix metalloproteinases (MMPs) are a family of Zinc-dependent endopeptidases that degrade extracellular matrix proteins. Human MMP-9 Matrix metalloproteinase-9 (Gelatinase-B), with a molecular weight of 82 Kd, is inhibited by TIMP-1 and alpha 2 macroglobulin. MMP-9 is secreted by tumor cells, endothelial cells, fibroblasts and leucocytes.MMP-9 is involved in inflammation, tissue modeling, wound healing and processing of cytokines. Expression of MMP-9 correlates with abnormal collagen deposition that accompanies pancreatic cancer, with the metastasis to lymph nodes by human breast cancer cells and invasion of regional vessels in giant cell tumors of bones. MMP-9 is elevated in saliva in patients with gingivitis and periodontal diseases.

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